RESEARCH
The Verma group is engaged in the research field of nanotechnology drug delivery and biomaterials. Our involves designing, development and evaluation of novel targeted & controlled release drug delivery systems for pharmaceutical, herbal, biomaterial and nanomedicine application which can be administered by conventional and unconventional non-invasive routes. Currently working on various modalities i.e. development of novel formulation (Nano-in Micro) for controlled delivery of peptide in lungs using Trojan horse approach; Novel nano-formulation for cold injury; pulmonary delivery of fixed dose combination for High Altitude Pulmonary Edema and Enzyme activated targeted nano-formulations of autophagy/apoptosis-inducing bioactive for drug resistant lung cancer.
Inhalation drug delivery systems
TUBERCULOSIS
Tuberculosis is an ongoing threat to global health, especially with the emergence of multi drug-resistant (MDR) and extremely drug-resistant(XDR) strains that are motivating the search for new treatment strategies. The aim is to develop and evaluate novel anti-tuberculosis nanoparticle formulations for direct pulmonary drug delivery, thereby maximizing efficacy and efficiency of the agent and minimizing its undesired side effects.
We also study the role of particulate drug delivery system on pathogens in their interaction with the host.
High Altitude Pulmonary Edema (HAPE) is life threatening emergency condition and it needs instant relief. But, most of the drugs used for the management of HAPE are orally administered which has low bioavailability (longer time for absorption) and hence longer time to elicit therapeutic effect. We are working to develop and evaluate dry powder inhalable particles containing combination of clinically proven combinations of drugs for pulmonary delivery for “instant” relief from HAPE.
Despite progress in understanding carcinogenesis, lung cancer is still a major cause of morbidity and mortality worldwide. We are working designing nad development of stimuli activated targeted nano-formulations of bioactives as potential therapy for drug resistant lung cancer
HIGH ALTITUDE PULMONARY EDEMA
LUNG CANCER
Transdermal drug delivery systems
COLD INJURY ( FROSTBITE)
Frostbite, the severest form of cold injury, is a major health hazard and a serious medical problem for the Armed Forces operating in snow-bound areas at high altitude like Siachen, Ladhak etc. It is a cold-induced injury of skin and tissue characterized by freezing and ischemic necrosis, when exposed to temperatures below the freezing point.Frost-bite is an emergency condition and it needs immediate relief. Keeping this in view, we are developing to design, characterize and evaluate nano-Spray gel based topical delivery for rapid relief and effective management of Frost-Bite injury.